The first clinical application of lipoic acid was used by German doctors to treat acute poisoning caused by the deadly mushroom (death cap, commonly known as "death cap"). By the 1980s, lipoic acid began to be discovered as a powerful antioxidant. Soluble and water-soluble characteristics, has the effect of resisting a variety of chronic diseases, so it is gradually attracting attention
American antioxidant pioneer Dr. Lester Packer mentioned in his book ( The Antioxidant Miracle, Chinese translation: miracle of antioxidants ) that lipoic acid is an ideal super antioxidant and an important role in the body's antioxidant network.
What is Alpha- lipoic acid?
Alpha-lipoic acid originated in 1937, when scientists Snell and others discovered that certain bacteria needed a compound in potato extract to grow. After a few years, the growth factor was isolated, which is sulfur. bitter
In recent years, it has been found that lipoic acid is a cofactor involved in the energy production and catabolism of granulocytes, and is closely related to glycolysis and citric acid cycle.
lipoic acid is a powerful antioxidant, and its potential functions include the following
(1) Inhibition of reactive oxygen species
(2) Regeneration of exogenous and endogenous antioxidants such as vitamin C, E, and glutathione
(3) Sequestration of metal ions
(4) Repair of oxidized proteins
(5) Regulation of gene transcription
(6) Inhibit the activation of nuclear factor kapp B (NF-kB)
Five proven benefits (benefits) of lipoic acid?
1. Lipoic acid is beneficial for blood lipid regulation
Dyslipidemia is defined as an increase in fasting total cholesterol and may also be accompanied by an increase in triglycerides. Dyslipidemia is associated with a range of health problems, including obesity, insulin resistance, and cardiovascular disease. Associated risk factors include: smoking, obesity, sedentary lifestyle, excess intake of saturated fat, intake of foods high in trans fat. Get In New zealand Alpha lipoic acid risk free.
A systematic literature review and meta-analysis (including 11 controlled clinical trials with a total of 452 adult participants) found that alpha-lipoic acid supplementation significantly reduced serum triacylglycerol, total cholesterol, and cholesterol) and low-density lipoprotein (low-density lipoprotein) levels, but no significant effect on serum high-density lipoprotein (high-density lipoprotein) .
In addition, subgroup analysis found that the effect of lipoic acid on blood lipid regulation was most significant in subjects with body mass index>30 kg/m2 and daily dose>600 mg
＊Conclusion: Supplementation of lipoic acid may have a positive effect on blood lipid regulation, but limited by the heterogeneity of the samples contained, more research is needed to further verify.
2. Lipoic acid benefits blood sugar control
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. According to the ability of pancreatic cells to secrete insulin, it is mainly divided into insulin-dependent type 1 diabetes (insufficient insulin secretion) and non-insulin-dependent type 2 diabetes (insufficient peripheral tissue insulin sensitivity and glucose uptake).
In the same patient, disorders of insulin secretion and defects in insulin action frequently coexist, and it is often unclear which are the primary causes of hyperglycemia. Obvious symptoms of hyperglycemia include polyuria, polydipsia, and weight loss, sometimes with polyphagia and blurred vision.
In addition, the timing of lipoic acid supplementation was dose-dependent with insulin changes (in a dose-dependent manner).
The underlying mechanism may be related to the stimulation of AMPK activity, phosphoinositol-3-kinase and protein kinase B by lipoic acid in skeletal muscle and adipose tissue, thereby improving the tyrosine phosphate of insulin receptors related to
＊Conclusion: Supplementation of lipoic may have a positive effect on blood sugar control, but due to the heterogeneity among studies, more studies are needed to confirm
3. Alpha Lipoic Acid Regulates Blood Pressure
Hypertension is an abnormal increase in arterial blood pressure, defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg. The gray area between systolic blood pressure of 120-139 mmHg and diastolic blood pressure of 80-89 mmHg was defined as prehypertension.
Elevated blood pressure is positively associated with the risk of stroke and coronary heart disease, in addition to complications including heart failure, peripheral vascular disease, renal impairment, retinal hemorrhage, and visual impairment
＊Conclusion: For subjects with blood pressure slightly higher than normal, oral lipoic acid has the effect of lowering blood pressure, but limited by the heterogeneity and small sample size of the included studies, more studies are needed to confirm
4. Alpha Lipoic Acid Improves Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy, the most common microvascular complication of diabetes, increases the risk of foot infections, ulcers, and non-traumatic amputations, ultimately leading to long-term disability
The main features are tingling, burning, pain, cramping, paresthesia or numbness, usually worse at night, causing sleep disturbance and severely affecting the patient's quality of life and ability to perform daily activities
Diabetic peripheral neuropathy is generally believed to be related to metabolic disorders, oxidative stress, vascular damage, nerve ischemia damage, and autoimmune disorders caused by long-term hyperglycemia
5. Alpha Lipoic Acid Improves Inflammatory Markers
Inflammation is an organism's physiological protective response (whether physical, chemical, or biological) to noxious stimuli that eliminates or neutralizes foreign organisms or substances and serves to restore homeostasis.
Typically, the inflammatory response starts within minutes and goes away within a few hours if all goes well. In contrast, chronic inflammation persists for weeks, months, or even years. If you are looking for some more supplements make sure to visit Therastore.
Increased chronic inflammation is associated with metabolic diseases, including type 2 diabetes, arteriosclerosis, endothelial dysfunction, vascular calcification, increased metalloproteinase activity, oxidative damage, and collagen degradation.